EFFECTS OF THE METHANOL EXTRACTS PHALERIA MACROCARPA (SCHEFF) BOERL FRUITS ON ANGIOTENSIN CONVERTING ENZYME (ACE) ACTIVITY

The present study was carried out to investigate the antihypertensive effect and Angiotensin Converting Enzyme activity of methanolic extract of Phaleria macrocarpa (Scheff) Boerl fruits in rats . Hypertension was induced experimentally by 10% w/v fructose diet ad libitum for 8 weeks. P. marcocarpa was given at the dose 0.5, 1 and 2 g/kg BW start at week 6 until week 8 and 1 g/kg BW for 8 weeks. Blood pressure was measured at baseline and at every weeks for 8 weeks using tail-cuff plethysmography. After completion of treatment schedule rats from each group were anesthetized with urethane (120 mg/100 gm, i. p.). Blood was collected and then centrifugated to obtain plasma and later store at-700C for analysis activity ACE plasma. The results suggests that methanol extract of Phaleria marcocarpha could prevent the development high blood pressure and normalized blood pressure in rat induced by diet rich in fructose. The results tend to suggest that methanol extracts of possesses antyhipertensive activity, through inhibition of angiotensin converting enzyme.

1.  UEU-Journal-14173-11_0085.pdf - 365 KB

• PENGARUH PERESEPAN ELEKTRONIK TERHADAP MUTU LAYANAN FARMASI DI RUMAH SAKIT �X� JAKARTA BARAT
• LAPORAN MAGANG; PENGELOLAAN PERBEKALAN FARMASI DI INSTALASI FARMASI RUMAH SAKIT PRATIWI (IBU & ANAK) KOTA TANGERANG TAHUN 2013
• GAMBARAN PENCATATAN DAN PELAPORAN PERBEKALAN FARMASI DI RUMAH SAKIT SIAGA RAYA
• ANALISIS PENGARUH PROFITABILITAS, UKURAN PERUSAHAAN, LEVERAGE DAN NILAI PERUSAHAAN TERHADAP PRAKTIK PERATAAN LABA (STUDI EMPIRIS : PADA PERUSAHAAN INDUSTRI FARMASI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE TAHUN 2008-2011)
• ANALISIS PENGARUH LEVERAGE, STRUKTUR MODAL DAN PROFITABILITAS TERHADAP PRICE EARNING RATIO (PER) PADA PERUSAHAAN FARMASI YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2002-2008
• ANALISIS FAKTOR � FAKTOR YANG MEMPENGARUHI STRUKTUR MODAL PADA PERUSAHAAN FARMASI DI BURSA EFEK INDONESIA (PERIODE 2006 � 2009)
• HUBUNGAN ANTARA MOTIVASI KERJA DAN KINERJA PETUGAS PELAYANAN RESEP OBAT JADI DI INSTALASI FARMASI RSUD CENGKARENG
• ANALISA PENGARUH PROFITABILITAS, TOTAL ASSET, INVENTORY TURNOVER, FINANCIAL LEVERAGE DAN OPINI AUDITOR TERHADAP PRAKTIK PERATAAN LABA PADA PERUSAHAAN FARMASI YANG TERDAFTAR DI BE1 PERIODE TAHUN 2007 - 2010
• GAMBARAN UMUM SISTEM MANAJEMEN LOGISTIK FARMASI DI RUMAH SAKIT ASSHOBIRIN TANGERANG TAHUN 2013
• PENATALAKSANAAN PENYIMPANAN FARMASI DI INSTALASI FARMASI RUMAH SAKIT MEDIKA PERMATA HIJAU JAKARTA BARAT